Targeted optimization refers to using diagnostic testing to detect underlying problems, which will direct initial steps towards recovering and optimizing one’s health

Below I’ve listed some of the tests I use to identify underlying problems

  • “Organic acids are products of the body’s metabolic pathways. Evaluation of these downstream metabolites from various metabolic pathways provides insight into important areas related to gut health, mitochondrial dysfunction, neurotransmitter status, indicators of detoxification and macronutrient breakdown and nutritional status. This makes organic acid testing a valuable tool to assess the functional need for essential nutrients, diet modification, antioxidant protection, detoxification, and other therapies.”

    “The Organic Acids Test (OAT) provides a comprehensive nutritional and metabolic snapshot of an individual’s overall health. The OAT measures 76 organic acids from one easy to collect urine sample.”

  • “The Myco-Metabolic Panel integrates the MycoTOX Profile™ with the Organic Acids Test (OAT), providing synergistic insights into toxic mold exposure and its negative impacts on critical bodily functions like energy production, detoxification, and nutrients.”

    “This powerful combination equips practitioners with patient insights to develop personalized and comprehensive treatment plans for mold exposure, while directly addressing underlying health issues for improved outcomes.”

  • “Vitamin D is primarily responsible for maintaining normal levels of calcium and phosphorus in the blood, which are essential for bone mineralization. However, it also has a significant impact on the expression of over 2,000 genes involved in cellular proliferation, differentiation, apoptosis, and angiogenesis. The immune-modulating effects of Vitamin D are profound and its deficiency is associated with many common and serious diseases, including certain cancers, diabetes, cardiovascular disease, and osteoporosis.”

    “MosaicDX’s Vitamin D Test is a useful tool in assessing Vitamin D levels, determining if sun exposure and dietary intake are adequate, and evaluating the likelihood of malabsorption or liver disease.”

  • “The Homocysteine Test is a serum assessment of homocysteine levels. Homocysteine is an amino acid requiring vitamins B12, B6 and folate to break down and metabolize to create other chemicals your body needs. High homocysteine levels may mean you have a vitamin deficiency. Without treatment, elevated homocysteine increases your risks for dementia, heart disease and stroke.”

  • “The Calcium + Magnesium Profile is an assessment of urinary levels of calcium and magnesium. Since magnesium works closely with calcium it is important to have an appropriate ratio of both of these critical minerals in order for them to be effective.”

  • “MosaicDX offers an Advanced Cholesterol Panel that goes beyond standard lipid panel measurements, providing a more comprehensive assessment of dyslipidemia and cardiovascular risk allowing you to gain a deeper understanding of your cholesterol levels.”

  • “Mycotoxins, produced by certain mold species, are some of the most prevalent toxins and can come from many sources, including buildings, vehicles, and food. These compounds have been recognized as a growing global health concern due to their acute and chronic adverse health impacts. Mycotoxin exposure can be challenging to diagnose without proper testing due to vague and often varied symptoms.”

    “The MycoTOX Profile™ is Mosaic Diagnostics’ most comprehensive assessment of mycotoxins. Our state-of-the-art urine-based assay accurately assesses levels of 11 different mycotoxins, including Aflatoxin M1, Ochratoxin A, Zearalenone, and Trichothecenes. The MycoTOX Profile has been designed to help clinicians uncover mycotoxin exposure and guide a therapeutic strategy for prevention and treatment.”

  • “Heavy metals can accumulate in the body and disrupt the balance of essential nutrients, and become toxic to organ systems. While certain elements are vital for proper body function, others such as mercury, lead, cadmium, aluminum, and arsenic are toxic to the human body and interfere with its functioning. These toxic metals have no known physiological functions and can cause harm to organ systems.”

    “MosaicDX offers various testing options, including urine, blood, stool, and hair samples, to evaluate the status of toxic metals and essential elements. This allows practitioners to select the most clinically appropriate option for their patients.”

  • “Glyphosate is the world’s most widely used herbicide and the primary toxic chemical in Roundup™ which is utilized by homeowners, municipalities, and farmers to prevent the growth of weeds and grasses. Studies have linked glyphosate exposure to chronic conditions and various types of cancer, such as non-Hodgkin lymphoma, renal tubule carcinoma, pancreatic islet-cell adenoma, and skin tumors. Glyphosate is also known to disrupt the balance of gut bacteria, reducing the ratio of beneficial to harmful bacteria.”

    “MosaicDX’s Glyphosate Test is a urine-based assay that assess an individual’s exposure to glyphosate. Additionally, MosaicDX offers testing of water samples to assist in identifying an important potential source of glyphosate exposure from contaminated drinking water.”

  • “Our daily lives expose us to hundreds of toxic chemicals from food, water, household products, personal care products, plastics, and air pollution. Exposure to these environmental toxicants wreak havoc on normal metabolic processes that lead to immune dysfunction, neurological disorders, endocrine disruption, certain types of cancer, and beyond.”

    “The TOXDetect Profile® is designed to pinpoint your environmental toxicant exposure. This profile measures 27 metabolites utilizing state-of-the-art LC-MS/MS technology, guaranteeing unmatched accuracy and reliability – all from a single urine sample.”

  • “The EnviroTOX™ suite offers practitioners a comprehensive set of panels for detecting and assessing toxic exposures and their health impacts. The EnviroTOX Burden panel is a key component, combining multiple profiles – including the TOXDetect Profile®, MycoTOX Profile™, and Metals – Toxic Elements – to provide an extensive screening for a wide range of toxic exposures.”

    “The other panels in the suite include the Organic Acids Test, which offers valuable insights into how these toxic exposures impact health. The foundational EnviroTOX panel, includes the Organic Acids Test, and TOXDetect Profile, with subsequent panels expanding to include the MycoTOX Profile and Metals – Toxic Elements, providing wider assessment of total body burden.”

  • “Our most comprehensive Lyme and co-infection combination panel includes Tickborne BBB Direct Detect dPCR with the Lyme Borrelia Nanotrap® urine antigen test to provide optimal coverage for the top flea and tick-borne infections at the genus level. Bartonella IgG Detect IFA adds enhances diagnostic accuracy when combined with BBB Direct Detect species genus level digital PCR Bartonella results.”

    “Tickborne BBB Direct Detect dPCR, confirms current infection by directly detecting genus-level DNA for a broad range of Bartonella, Borrelia, and Babesia species (spp) in whole blood. This approach ensures that less common species are not missed.”

    “Lyme Borrelia Direct Detect – Nanotrap assesses the current presence of Lyme Borrelia infection in urine. Concentrations of Lyme Borrelia are so low in the blood that a blood draw is unlikely to capture the pathogen in the test tube. The Nanotrap® test is targeting the OspA protein, which can be found on the surface of Borrelia species.”

    “Bartonella IgG Detect IFA confirms antibodies against the four most common species of infection: Bartonella henselae, Bartonella koehlerae, Bartonella quintana, and Bartonella vinsonii berkhoffii.”

    “Combining direct and indirect testing methods–specifically for Bartonella infection–enhances diagnostic accuracy, especially for patients with complex clinical presentations. MosaicDX recommends maximizing diagnostic data by testing for both antibodies (indirect) and DNA evidence of pathogens (direct) for Bartonella, as each test method provides critical support. Tickborne BBB Direct Detect dPCR includes tests for Borrelia, Babesia and Bartonella at a genus level for all associated pathogens and Bartonella IgG Detect uses the IFA method to detect IgG to the top four Bartonella species affecting humans in North America.”

  • “Discover the Power of MosaicDX’s Lyme Borrelia Direct Detect profile that provides more sensitive direct detection for Lyme Borrelia at all stages of Lyme disease than standard methods. Identifies positive cases missed by conventional Two-Tiered Testing (TTT). “

    • “Up to 2x more sensitive than conventional antibody testing”

    • “Confirms cases missed by antibody testing”

    • “Easy at-home or in-office urine sample collection”

    “More Sensitive and Reliable Direct Detection”

    • “100% sensitivity and 98% specificity in 24/24 patients with EM rash.”

  • “Exposure to infected fleas, tickes, spiders, and lice, or companion and wild animals can cause Bartonellosis. Bartonella henselae, the species responsible for Cat Scratch Disease can be present on a cat or kitten’s claw or mouth and spread through a scratch, bit, or lick.”

    “Bartonella can cause severe, life-threatening infections or symptoms in humans and animals. Early detection makes the infection treatable, which can prevent chronic illness. Bartonella are intracellular parasites and can live and reproduce both inside and outside of host cells. Bartonella infections are stealthy and difficult to diagnose because the bacteria can invade and hide in host cells and create a niche where they can survive and multiply, and evade the immune system.”

    “Discover the Power of MosaicDX’s Bartonella IgG Detect IFA profile”

    “Bartonella IgG Detect – IFA utilizes authentic cell-cultured clinical isolates for Bartonella species that most commonly affect humans in North America: B. henselae, B. vinsonii, B. berkhoffii, B. koehlerae.”

    • “Confirms prior exposure and potential current infection: Antibody results reported in titers.”

    • “Broad IgG antibody coverage: Confirms exposure to the four main species affecting humans in North America.”

    • “Accurate: Provides precise, semi-quantitative antibody levels and accurate titers.”

    • “Minimizes cross-reactivity: Ensures reliable and specific results, addressing common challenges in serological testing.”

    • “Sensitive and Specific: Uses cell-culture-derived antigens from clinical isolates, not synthetic.”

  • “The most sensitive test methodology available for direct detection of Bartonella, Babesia, and Borrelia species (spp). (BBB) pathogens. “

    “People can be exposed to Bartonella, Babesia, and Borrelia through exposure to ticks, fleas, lice, sand flies, and potentially spiders. These vectors can carry multiple pathogens at once, making co-infections common. These stealth pathogens can cause overlapping, persistent symptoms that are often misdiagnosed. Identifying which of these infections are present helps providers tailor treatment more effectively—especially since each requires a different therapeutic approach. Without proper testing, co-infections can be missed, leading to incomplete or ineffective care.”

    “Discover the Power of MosaicDX’s Tickborne BBB Direct Detect”

    “Direct testing is particularly valuable in detecting the current presence of pathogens when antibody responses might be absent or unclear. Many patients with detectable spp. DNA never develop detectable antibodies, while others may only show very low titers. The result is that many patients with current presence of pathogens are missed by both conventional PCR and antibody testing.”

    “Tickborne BBB Direct Detect dPCR, confirms the presence of pathogens by directly detecting genus-level DNA for a broad range of Bartonella, Borrelia, and Babesia species (spp) in whole blood. This approach ensures that less common species are not missed.”

  • “Hormones play a vital role in maintaining physical and mental health as imbalances can lead to serious health problems. Both men and women produce hormones like estrogen and testosterone, and balance is key for optimal health.”

    “The old “one-size-fits-all” approach to hormone replacement therapy is outdated, MosaicDX offers comprehensive salivary hormone profiles that measure both sex and stress hormones. Salivary measurement of hormones is non-invasive and convenient to asses unbound biologically active hormone levels. Our profiles help identify hormonal imbalances, allowing for personalized hormone replacement therapies and nutritional interventions.”

    Comprehensive Analytes

    Estradiol (E2)

    Progesterone (Pg)

    Testosterone

    DHEA

    Cortisol AM30

    Cortisol Noon

    Cortisol Evening

    Cortisol Night

    Pg/E2 Ratio

    Comprehensive Plus (with three additional analytes)

    Estrone (E1)

    Estriol (E3)

    EQ (E3/(E1 + E2)) Ratio

  • “Imbalances in gastrointestinal function can lead to both local and systemic health issues, with the gut microbiome playing a vital role in supporting overall health. Our Comprehensive Stool Analysis profile helps identify the underlying causes of acute and chronic symptoms, enabling providers to create personalized treatment plans.”

    “The Comprehensive Stool Analysis measures key markers of digestion, absorption, and intestinal function, including a comprehensive bacteriology and yeast culture to detect beneficial, imbalanced, and dysbiotic flora. We use gold standard methods, such as PCR, to identify infectious pathogens and parasites, and perform antimicrobial susceptibility testing on cultured bacterial and fungal species to recommend prescriptive and natural agents.”

  • “For over 29 years, Mosaic Diagnostics has exemplified innovation and adaptability in this evolving landscape. Leveraging a robust dataset of 79,000 global samples, we are redefining IgG food sensitivity testing and reporting standards. Our goal is to provide healthcare providers with accurate, representative data that reflects the dietary diversity of today’s population, and our reference ranges align with the varied diets and demographics of the modern world.”

    “IgG food sensitivities provide a useful guide for personalized rotation/elimination diets with clinical impact associated with a variety of diseases. People may continue to eat offending foods, unaware of their potential adverse effects, because symptoms associated with food sensitivities may occur hours or days after the offending food was eaten.”

    “MosaicDX’s IgG Food MAP measures antibodies to common foods, herbs, and spices typically found in Western, Asian, and Mediterranean diets also include results for Candida and Yeast. This test is available in both serum and dried blood spot formats, making it easy and convenient for patients. By identifying food sensitivities, our test will help individuals customize their diet leading to improvements in overall health and wellbeing.”

  • “Inhalant (or respiratory) allergens are environmental substances that can trigger an allergic reaction when they are inhaled into the body, including common substances such as pollen, grasses, dust mites, animal dander, mold spores, and even some types of chemicals. Elevated levels of IgE can be observed when the body overreacts to these typically harmless substances.  This type of allergic reaction can result in a wide range of symptoms from mild (sneezing, runny nose, congestion) to severe and potentially life-threatening (anaphylaxis). “

    “MosaicDX’s IgE Inhalant Allergy Test is a blood-based (serum) panel that focuses on the presence of inhalant specific allergens across several clinically important groups: pets, dust, insects, molds, and pollen.”

  • “Mold allergy is a type of allergic reaction that occurs when an individual’s immune system is exposed to mold spores or mold cell components – typically via inhalation, ingestion, and/or contact with the skin. Molds are a type of fungi which grow in moisture-rich environments such as damp areas in homes like bathrooms and basements, and high humidity areas in buildings or vehicles. In addition, certain occupations have been identified to increase risk for mold exposure: construction industry (e.g., builders, plumbers, HVAC technicians), farmers, food industry workers, janitors/cleaners, and health care workers.”

    “MosaicDX’s IgE Mold Allergy Test measures an individual’s total immunoglobulin E (IgE) level as well as allergen specific IgE levels to 13 mold allergens, including common mold allergens like Alternaria, Aspergillus, Cladosporium, and Penicillium. This panel provides valuable insight into potential triggers for mold allergy symptoms in sensitive individuals.”